|
KMID : 0613820090190070976
|
|
Journal of Life Science
2009 Volume.19 No. 7 p.976 ~ p.982
|
|
|
Effect of Alliin on Vascular Functions
|
|
Seo Jeong-Hwa
Kim Jeong-Min
Ahn Sun-Young
Cho Jin-Gu
Kim Jong-Min
Park Heon-Yong
|
|
|
Abstract
|
|
|
|
Little is known about the cardiovascular roles of alliin, a functional component in garlic that has been used as food material. Thus, we examined a broad range of cardiovascular activities of alliin in this study. From our in vitro experiments, alliin was determined to act as a stimulant to induce endothelial cell proliferation and endothelial cell migration. Since endothelial cell proliferation and migration are highly associated with angiogenesis and wound healing, alliin is suggested as a regulator to control angiogenesis and wound healing. In addition, alliin was elucidated to prevent lipopolysaccharide (LPS)-induced adhesion of THP-1 leukocytes to endothelial cells and LPS-induced homotypic THP-1 cell aggregation. These inhibitory effects indicate that alliin is likely to act as an anti-atherosclerotic and anti-thrombotic factor, because leukocytic adhesion to endothelial cells and homotypic leukocyte aggregation are highly associated with atherosclerosis and thrombosis, respectively. Our additional findings show that alliin has no effect on the production of nitric oxide (NO), an important vasoregulator. In conclusion, alliin is suggested as a regulator for controlling various cardiovascular functions.
|
|
|
KEYWORD
|
|
|
Alliin, endothelial cells, adhesion, migration, proliferation
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|